1. Baquero F, Beis K, Craik DJ, Li Y, Link AJ, Rebuffat S, Salomón R, Severinov K, Zirah S, Hegemann JD: The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide. Natural Product Reports 2024, in press,
  2. Carson DV, Zhang Y, So L, Cheung-Lee WL, Jaramillo Cartagena A, Darst SA, Link AJ: Discovery, Characterization, and Bioactivity of the Achromonodins: Lasso Peptides Encoded by Achromobacter. Journal of Natural Products 2023, 86: 2448-2456.
  3. Choi B, Acuna A, Koos JD, Link AJ: A large-scale bioinformatic study of graspimiditides and structural characterization of albusimiditide. ACS Chemical Biology 2023, 18: 2394-2404.
  4. Cao L, Do T, Zhu A, Duan J, Alam N, Link AJ: Genome Mining and Discovery of Imiditides, a Family of RiPPs with a Class-defining Aspartimide Modification. Journal of the American Chemical Society 2023, 145: 18834-18845.
  5. Choi B, Link AJ: Discovery, Function, and Engineering of Graspetides. Trends in Chemistry 2023, 5: 620-633.
  6. Thokkadam A, Do T, Ran X, Brynildsen MP, Yang ZJ, Link AJ: A High-Throughput Screen Reveals the Structure-Activity Relationship of the Antimicrobial Lasso Peptide Ubonodin. ACS Central Science 2023, 9: 540-550.
  7. Cao L, Elashal HE, Link AJ: Kinetics of Aspartimide Formation and Hydrolysis in Lasso Peptide Lihuanodin. Biochemistry 2023, 62: 695-699.
  8. Juarez RJ, Jiang Y, Tremblay M, Shao Q, Link AJ, Yang ZJ: LassoHTP: A High-Throughput Computational Tool for Lasso Peptide Structure Construction and Modeling. Journal of Chemical Information and Modeling 2023, 63: 522-530.
  9. Carson DV, Patino M, Elashal HE, Jaramillo Cartagena A, Zhang Y, Whitley ME, So L, Kayser-Browne AK, Earl AM, Bhattacharyya RP, Link AJ: Cloacaenodin, an antimicrobial lasso peptide with activity against Enterobacter. ACS Infectious Diseases 2023, 9: 111-121.
  10. Do T, Link AJ: Protein Engineering in Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs). Biochemistry 2023, 62: 201-209.
  11. Choi B, Elashal HE, Cao L, Link AJ: Mechanistic Analysis of the Biosynthesis of the Aspartimidylated Graspetide Amycolimiditide. Journal of the American Chemical Society 2022, 144: 21628-21639.
  12. Elashal HE, Koos JD, Cheung-Lee WL, Choi B, Cao L, Richardson MA, White HL, Link AJ: Biosynthesis and characterization of fuscimiditide, an aspartamidylated graspetide. Nature Chemistry 2022, 14: 1325-1334.
  13. Ozden S, Monti S, Tozzini V, Dutta NS, Gili S, Caggiano N, Link AJ, Pugno NM, Higgins J, Priestley RD, Arnold CB: Egg protein derived ultralightweight hybrid monolithic aerogel for water purification. Materials Today 2022, 59: 46-55.
  14. Do T, Thokkadam A, Leach R, Link AJ: Phenotype-guided comparative genomics identifies the complete transport pathway of the antimicrobial lasso peptide ubonodin in Burkholderia. ACS Chemical Biology 2022, 17: 2332-2343.
  15. Wan X, Link AJ, Brynildsen MP: Translational Fusion to Hmp Improves Heterologous Protein Expression. Microorganisms 2022, 10: 358.
  16. Schröder HV, Stadlmeier M, Wühr M, Link AJ: The Shuttling Cascade in Lasso Peptide Benenodin-1 is Controlled by Non-Covalent Interactions. Chemistry-A European Journal 2022, 28: e2021036.
  17. Schröder HV, Zhang Y, Link AJ: Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides. Nature Chemistry 2021, 13: 850-857.
  18. Cao L, Beiser M, Koos JD, Orlova M, Elashal HE, Schröder HV, Link AJ: Cellulnodin-2 and Lihuanodin: Lasso Peptides with an Aspartimide Post-Translational Modification. Journal of the American Chemical Society 2021, 143: 11690-11702.
  19. Nerger BA, Jaslove JM, Elashal HE, Mao S, Kosmrlj A, Link AJ, Nelson CM: Local accumulation of extracellular matrix regulates global morphogenetic patterning in the developing mammary gland. Current Biology 2021, 31: 1-15.
  20. Cao L, Do T, Link AJ: Mechanisms of Action of Ribosomally Synthesized and Posttranslationally Modified Peptides (RiPPs). Journal of Industrial Microbiology and Biotechnology 2021, 48: kuab005.
  21. Montalbán-López M, Scott TA, Ramesh S, Rahman IR, van Heel A, Viel JH, Bandarian V, Dittmann E, Genilloud O, Goto Y, Grande Burgos MJ, Hill C, Kim S, Koehnke J, Latham JA, Link AJ, Martínez B, Nair SK, Nicolet Y, Rebuffat S, Sahl HG, Sareen D, Schmidt EW, Schmitt L, Severinov K, Süssmuth RD, Truman AW, Wang H, Weng JK, van Wezel GP, Zhang Q, Zhong J, Piel J, Mitchell DA, Kuipers OP, van der Donk, WA: New developments in RiPP discovery, enzymology and engineering. Natural Product Reports 2021, 38: 130-239.
  22. Chou WK, Vaikunthan M, Schröder HV, Link AJ, Kim H, Brynildsen MP: Synergy Screening Identifies a Compound That Selectively Enhances the Antibacterial Activity of Nitric Oxide. Frontiers in Bioengineering and Biotechnology 2020, 8: 1-18.
  23. Cheung-Lee WL, Parry ME, Zong C, Jaramillo Cartagena A, Darst SA, Connell ND, Russo R, Link AJ: Discovery of ubonodin, an antimicrobial lasso peptide active against members of the Burkholderia cepacia complex. ChemBioChem 2020, 21: 1335-1340.
  24. Cheung-Lee WL, Cao L, Link AJ: Pandonodin: a proteobacterial lasso peptide with an exceptionally long C-terminal tail. ACS Chemical Biology 2019, 14: 2783-2792.
  25. Cheung-Lee WL, Link AJ: Genome mining for lasso peptides: past, present, and future. Journal of Industrial Microbiology & Biotechnology 2019, 46: 1371-1379.
  26. Cheung-Lee WL, Parry ME, Jaramillo Cartagena A, Darst SA, Link AJ: Discovery and structure of the antimicrobial lasso peptide citrocin. Journal of Biological Chemistry 2019, 294: 6822-6830.
  27. Braffman N, Piscotta FJ, Hauver J, Campbell EA, Link AJ, Darst SA: Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. Proceedings of the National Academy of Sciences, USA 2019, 116: 1273-1278.
  28. Piscotta FJ, Jeffrey PD, Link AJ: ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism. Proceedings of the National Academy of Sciences, USA 2019, 116: 826-834.
  29. Koos JD, Link AJ: Heterologous and in vitro reconstitution of fuscanodin, a lasso peptide from Thermobifida fusca. Journal of the American Chemical Society 2019, 141: 928-935.
  30. Elashal HE, Cohen RD, Elashal HE, Zong CH, Link AJ, Raj M: Cyclic and Lasso Peptides: Sequence Determination, Topology Analysis, and Rotaxane Formation. Angewandte Chemie-International Edition 2018, 57: 6150-6154.
  31. Zong C, Cheung-Lee WL, Elashal HE, Raj M, Link AJ: Albusnodin: an acetylated lasso peptide from Streptomyces albus. Chemical Communications 2018, 54: 1339-1342.
  32. Zong C, Wu MJ, Qin JZ, Link AJ: Lasso Peptide Benenodin-1 is a Thermally Actuated [1]Rotaxane Switch. Journal of the American Chemical Society 2017, 139: 10403-10409.
  33. Chekan JR, Koos JD, Zong C, Maksimov MO, Link AJ, Nair SK: Structure of the Lasso Peptide Isopeptidase Identifies a Topology for Processing Threaded Substrates. Journal of the American Chemical Society 2016, 138: 16452-16458.
  34. Allen CD, Link AJ: Self-Assembly of Catenanes from Lasso Peptides. Journal of the American Chemical Society 2016, 138: 14214-14217.
  35. Cheung WL, Chen MY, Maksimov MO, Link AJ: Lasso Peptide Biosynthetic Protein LarB1 Binds Both Leader and Core Peptide Regions of the Precursor Protein LarA. ACS Central Science 2016, 2: 702-709.
  36. Allen CD, Chen MY, Trick AY, Le DT, Ferguson AL, Link AJ: Thermal Unthreading of the Lasso Peptides Astexin-2 and Astexin-3. ACS Chemical Biology 2016, 11: 3043-3051.
  37. Arnaudo AM, Link AJ, Garcia BA: Bioorthogonal Chemistry for the Isolation and Study of Newly Synthesized Histones and their Modifications. ACS Chemical Biology 2016, 11: 782-791.
  38. Zong C, Maksimov MO, Link AJ: Construction of Lasso Peptide Fusion Proteins. ACS Chemical Biology 2016, 11: 61-68.
  39. Maksimov MO, Koos JD, Zong C, Lisko B, Link AJ: Elucidating the Specificity Determinants of the AtxE2 Lasso Peptide Isopeptidase. Journal of Biological Chemistry 2015, 290: 30806-30812.
  40. Link AJ: Leading the way to RiPPs. Nature Chemical Biology 2015, 11: 551-552.
  41. Futran AS, Kyin S, Shvartsman SY, Link AJ: Mapping the binding interface of ERK and transcriptional repressor Capicua using photocrosslinking. Proceedings of the National Academy of Sciences 2015, 112: 8590-8595.
  42. Piscotta FJ, Tharp JM, Liu WR, Link AJ: Expanding the chemical diversity of lasso peptide MccJ25 with genetically encoded noncanonical amino acids. Chemical Communications 2015, 51: 409-412.
  43. Abdeljabbar DM, Piscotta FJ, Zhang SY, Link AJ: Protein stapling via azide-alkyne ligation. Chemical Communications 2014, 50: 14900-14903.
  44. Maksimov MO, Link AJ: Prospecting Genomes for Lasso Peptides. Journal of Industrial Microbiology & Biotechnology 2014, 41: 333-344.
  45. Futran AS, Link AJ, Seger R, Shvartsman SY: ERK as a Model for Systems Biology of Enzyme Kinetics in Cells. Current Biology 2013, 23: R972-R979.
  46. Maksimov MO, Link AJ: Discovery and Characterization of an Isopeptidase that Linearizes Lasso Peptides. Journal of the American Chemical Society 2013, 135: 12038-12047.
  47. Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian K-D, Fischbach MA, Garavelli JS, Goransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Muller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJT, Rebuffat S, Ross RP, Sahl H-G, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Sussmuth RD, Tagg JR, Tang G-L, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA: Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports 2013, 30:108-160.
  48. Maksimov MO, Pelczer I, Link AJ: Precursor-centric genome-mining approach for lasso peptide discovery. Proceedings of the National Academy of Sciences 2012, 109:15223-15228.
  49. Maksimov MO, Pan SJ, Link AJ: Lasso peptides: structure, function, biosynthesis, and engineering. Natural Product Reports 2012, 29: 996-1006.
  50. Park EJ, Wagenaar T, Zhang SY, Link AJ, Prud'homme RK, Koberstein JT, Turro NJ: Using Light to Covalently Immobilize and Pattern Nanoparticles onto Surfaces. Langmuir 2012, 28: 10934-10941.
  51. Zhang SY, Chan KH, Prud'homme RK, Link AJ: Synthesis and Evaluation of Clickable Block Copolymers for Targeted Nanoparticle Drug Delivery. Molecular Pharmaceutics 2012, 9: 2228-2236.
  52. Pan SJ, Rajniak J, Maksimov MO, Link AJ: The Role of a Conserved Threonine Residue in the Leader Peptide of Lasso Peptide Precursors. Chemical Communications 2012, 48: 1880-1882.
  53. Pan SJ, Rajniak J, Cheung WL, Link AJ: Construction of a Single Polypeptide that Matures and Exports the Lasso Peptide Microcin J25. ChemBioChem 2012, 13: 367-370.
  54. Zhang SY, Long A, Link AJ: A comparison of two strategies for affinity maturation of a BH3 peptide toward pro-survival Bcl-2 proteins. ACS Synthetic Biology 2012, 1: 89-98.
  55. Abdeljabbar DM, Song HJ, Link AJ: Trichoderma reesei cellobiohydrolase II is associated with the outer membrane when overexpressed in Escherichia coli. Biotechnology Letters 2012, 34: 91-96.
  56. Zhang SY, Link AJ: Bcl-2 Family Interactome Analysis Using Bacterial Surface Display. Integrative Biology 2011, 3: 823-831.
  57. Abdeljabbar DM, Klein TJ, Link AJ: An Engineered Methionyl-tRNA Synthetase Enables Azidonorleucine Incorporation in Methionine Prototrophic Bacteria. ChemBioChem 2011, 12: 1699-1702.
  58. Zhang SY, Prud’homme RK, Link AJ: Block Copolymer Nanoparticles as Nanobeads for the Polymerase Chain Reaction. Nano Letters 2011, 11: 1123-1126.
  59. Pan SJ, Link AJ: Sequence Diversity in the Lasso Peptide Framework: Discovery of Functional Microcin J25 Variants with Multiple Amino Acid Substitutions. Journal of the American Chemical Society 2011, 133: 5016-5023.
  60. Zhang SY, Adamson DH, Prud’homme RK, Link AJ: Photocrosslinking the Polystyrene Core of Block-Copolymer Nanoparticles. Polymer Chemistry 2011, 2: 665-671.
  61. Pan SJ, Cheung WL, Fung HK, Floudas CA, Link AJ: Computational Design of Functional Variants of the Antimicrobial Peptide Microcin J25. Protein Engineering Design & Selection 2011, 24: 275-282.
  62. Ferguson AL, Zhang SY, Dikiy I, Panagiotopoulos AZ, Debenedetti PG, Link AJ: An Experimental and Computational Investigation of Spontaneous Lasso Formation in Microcin J25. Biophysical Journal 2010, 99: 3056-3065.
  63. Mannoor MS, Zhang SY, Link AJ, McAlpine MC: Electrical detection of pathogenic bacteria via immobilized antimicrobial peptides. Proceedings of the National Academy of Sciences 2010, 107: 19207-19212.
  64. Cheung WL, Pan SJ, Link AJ: Much of the Microcin J25 Leader Peptide is Dispensable. Journal of the American Chemical Society 2010, 132: 2514-2515.
  65. Pan SJ, Cheung WL, Link AJ: Engineered Gene Clusters for the Production of the Antimicrobial Peptide Microcin J25. Protein Expression and Purification 2010, 71: 200-206.
  66. Abdeljabbar DM, Klein TJ, Zhang SY, Link AJ: A Single Genomic Copy of an Engineered Methionyl-tRNA Synthetase Enables Robust Incorporation of Azidonorleucine into Recombinant Proteins in E. coli. Journal of the American Chemical Society 2009, 131: 17078-17079.
  67. Sun JJ, Abdeljabbar DM, Clarke N, Bellows ML, Floudas CA, Link AJ: Reconstitution and Engineering of Apoptotic Protein Interactions on the Bacterial Cell Surface. Journal of Molecular Biology 2009, 394: 297-305.
  68. Tang Y, Wang P, Van Deventer JA, Link AJ, Tirrell DA: Introduction of an Aliphatic Ketone into Recombinant Proteins in a Bacterial Strain that Overexpresses an Editing-Impaired Leucyl-tRNA Synthetase. Chembiochem 2009, 10: 2188-2190.
  69. Xu LY, Link AJ: Stress responses to heterologous membrane protein expression in Escherichia coli. Biotechnology Letters 2009, 31: 1775-1782.
  70. Dieterich DC, Link AJ: Click Chemistry in Protein Engineering, Design, Detection and Profiling. in Click Chemistry in Biotechnology and Materials Science, Wiley, ed. Joerg Lahann.
  71. Link AJ, Skretas G, Chari NS, Strauch EM, Georgiou, G: Efficient production of membrane-integrated and detergent-soluble G protein-coupled receptors in Escherichia coli Protein Science 2008, 17: 1857-1863.
  72. Strable E, Prasuhn DE, Udit AK, Brown S, Link AJ, Ngo JT, Lander G, Quispe J, Potter CS, Carragher B, et al.: Unnatural amino acid incorporation into virus-like particles. Bioconjugate Chemistry 2008, 19: 866-875.
  73. Yoo TH, Link AJ, Tirrell DA: Evolution of a fluorinated green fluorescent protein. Proceedings of the National Academy of Sciences 2007, 104: 13887-13890.
  74. Link AJ, Jeong KJ, Georgiou, G: Beyond toothpicks: new methods for isolating mutant bacteria. Nature Reviews Microbiology 2007, 5: 680-688.
  75. Link AJ, Vink MKS, Tirrell DA: Synthesis of the functionalizable methionine surrogate azidohomoalanine using Boc-homoserine as precursor. Nature Protocols 2007, 2: 1884-1887.
  76. Link AJ, Vink MKS, Tirrell DA: Preparation of the functionalizable methionine surrogate azidohomoalanine via copper-catalyzed diazo transfer Nature Protocols 2007, 2: 1879-1883.
  77. Link AJ, Georgiou G: Advances and Challenges in Membrane Protein Expression. AIChE Journal 2007, 53: 752-756.
  78. Dieterich DC, Lee JJ, Link AJ, Graumann J, Tirrell DA, Schuman EM: Labeling, detection and identification of newly synthesized proteomes with bioorthogonal non-canonical amino-acid tagging. Nature Protocols 2007, 2: 532-540.
  79. Link AJ, Vink MKS, Agard NJ, Prescher JA, Bertozzi CR, Tirrell DA: Discovery of aminoacyl-tRNA synthetase activity through cell-surface display of noncanonical amino acids. Proceedings of the National Academy of Sciences 2006, 103: 10180-10185.
  80. Dieterich DC, Link AJ, Graumann J, Tirrell DA, Schuman EM: Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal non-canonical amino acid tagging (BONCAT). Proceedings of the National Academy of Sciences 2006, 103: 9482-9487.
  81. Link AJ, Tirrell DA: Reassignment of Sense Codons In vivo. Methods 2005, 36: 291-298.
  82. Link AJ, Vink MKS, Tirrell DA: Presentation and Detection of Azide Functionality in
    Bacterial Cell Surface Proteins. Journal of the American Chemical Society 2004, 126: 10598-10602.
  83. Link AJ, Mock ML, Tirrell DA: Non-canonical Amino Acids in Protein Engineering. Current Opinion in Biotechnology 2003, 14: 603-609.
  84. Link AJ, Tirrell DA: Cell Surface Labeling of Escherichia coli via Copper(I)- Catalyzed [3+2] Cycloaddition. Journal of the American Chemical Society 2003, 125: 11164-11165.
  85. Bradley AZ, Link AJ, Biswas K, Kahne D, Schwartz J, Jones M, Zhu ZD, Platz MS: Hydrogen Abstraction on Photolysis of a Naphthocarborane. Tetrahedron Letters 2000, 41: 8691-8694.